Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.42 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.42 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30620040 | 0.72 | MAP2K4 (0.46) | MAP2K4MAPK1MAPKAPK2MAPKAPK3MAPK6 | |
| SCHEMBL30620072 | 0.70 | MAP2K4 (0.44) | MAP2K4MAPK1MAPKAPK2MAPKAPK3MAPK6 | |
| SCHEMBL14863426 | 0.70 | MAPK1 (0.48) | MAPK1JAK2JAK1MAPK3 | |
| SCHEMBL14863425 | 0.70 | MAPK1 (0.48) | MAPK1JAK2JAK1MAPK3 | |
| SCHEMBL23559721 | 0.70 | MAP2K4 (0.58) | MAP2K4MAPK1MAPKAPK2MAPKAPK3MAPK6 | |
| SCHEMBL14873241 | 0.68 | MAPK1 (0.47) | MAPK1TTKMAPK3 | |
| SCHEMBL4898881 | 0.67 | MAP2K4 (0.50) | MAP2K4MAPK1MAPKAPK2MAPKAPK3MAPK6 | |
| SCHEMBL14863667 | 0.67 | MAP2K4 (0.51) | CHEK2MAP2K4MAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL5377609 | 0.67 | MAP2K4 (0.65) | MAP2K4MAPK1MAPKAPK2MAPKAPK3MAPK6 | |
| SCHEMBL9987358 | 0.66 | MAPK1 (0.66) | MAP2K4MAPK1MAPKAPK2MAPKAPK3MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |