SCHEMBL20211348

SCHEMBL20211348

CC=Nc1c(C(C)(C)C)cccc1C(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.44
ALOX12 P18054 1/20 0.40
GABRA1 P14867 1/20 0.39
GABRB2 P47870 1/20 0.39
ALDH1A1 P00352 2/20 0.38
TSHR P16473 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
PLA2G1B P04054 1/20 0.33
MAPT P10636 1/20 0.33
ATG4B Q9Y4P1 1/20 0.33
KIF11 P52732 1/20 0.33
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20954046 1.00 CA2 (0.44) CA2ALOX12GABRA1GABRB2ALDH1A1
SCHEMBL242955 0.84 CA2 (0.46) CA2ALOX12GABRA1GABRB2ALDH1A1
SCHEMBL242956 0.84 CA2 (0.46) CA2ALOX12GABRA1GABRB2ALDH1A1
SCHEMBL26846725 0.80 CA2 (0.37) CA2ALOX12GABRA1GABRB2ALDH1A1
SCHEMBL30132733 0.76 ALDH1A1 (0.50) CA2ALOX12GABRA1GABRB2ALDH1A1
SCHEMBL1758933 0.74 CA2 (0.38) CA2ALOX12GABRA1GABRB2ALDH1A1
SCHEMBL1758934 0.74 CA2 (0.38) CA2ALOX12GABRA1GABRB2ALDH1A1
SCHEMBL14280786 0.74 ALDH1A1 (0.49) CA2ALOX12GABRA1GABRB2ALDH1A1
SCHEMBL361328 0.71 CA2 (0.48) CA2ALOX12GABRA1GABRB2ALDH1A1
SCHEMBL16771251 0.71 CA2 (0.48) CA2ALOX12GABRA1GABRB2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114787173-A Metal complexes 默克专利有限公司 2022-07-22 CN disclosed
CN-113646317-A Metal complexes 默克专利有限公司 2021-11-12 CN disclosed
CN-109563115-B Method for separating enantiomeric mixtures of metal complexes 默克专利有限公司 2021-10-01 CN disclosed
CN-107849077-B Bridged electroluminescent metal complexes for use in electronic devices 默克专利有限公司 2021-02-26 CN disclosed
CN-105916868-B Metal complexes 默克专利有限公司 2020-06-23 CN disclosed
CN-105555792-B Polycyclic phenylpyridine iridium complexes and derivatives thereof for OLEDs 默克专利有限公司 2019-12-31 CN disclosed
EP-3478698-A1 METHOD FOR THE SEPARATION OF ENANTIOMERIC MIXTURES FROM METAL COMPLEXES Merck Patent GmbH (DE) 2019-05-08 EP disclosed
EP-3328872-A1 ELECTROLUMINESCENT BRIDGED METAL COMPLEXES FOR USE IN ELECTRONIC DEVICES Merck Patent GmbH (DE) 2018-06-06 EP disclosed