Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20212446 | 1.00 | CYP3A4 (0.76) | CYP3A4MAPTNPSR1KDM4EALDH1A1 | |
| SCHEMBL13191163 | 0.91 | CYP3A4 (0.72) | CYP3A4MAPTNPSR1KDM4EALDH1A1 | |
| SCHEMBL1699718 | 0.88 | CYP3A4 (0.62) | CYP3A4MAPK14CREBBP | |
| SCHEMBL1699715 | 0.88 | CYP3A4 (0.62) | CYP3A4MAPK14CREBBP | |
| Bi-224436 SCHEMBL29450566 | 0.87 | CYP3A4 (1.00) | CYP3A4MAPTNPSR1KDM4EALDH1A1 | |
| Bi-224436 SCHEMBL12987894 | 0.87 | CYP3A4 (1.00) | CYP3A4MAPTNPSR1KDM4EALDH1A1 | |
| SCHEMBL13191539 | 0.83 | CYP3A4 (0.65) | CYP3A4MAPTNPSR1KDM4EALDH1A1 | |
| SCHEMBL13191166 | 0.83 | CYP3A4 (0.87) | CYP3A4MAPTNPSR1KDM4EALDH1A1 | |
| SCHEMBL13191540 | 0.82 | CYP3A4 (0.85) | CYP3A4MAPTNPSR1KDM4EALDH1A1 | |
| SCHEMBL26076852 | 0.82 | CYP3A4 (0.78) | CYP3A4MAPK14EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10544177-B2 | Chiral dihydrobenzooxaphosphole ligands and synthesis thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-01-28 | — | — | US | disclosed |
| EP-3551638-A2 | NOVEL CHIRAL DIHYDROBENZOOXAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF | Boehringer Ingelheim International GmbH (DE) | 2019-10-16 | — | — | EP | disclosed |
| US-20190144475-A1 | NOVEL CHIRAL DIHYDROBENZOOXAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2019-05-16 | — | — | US | disclosed |
| US-10221203-B2 | Chiral dihydrobenzooxaphosphole ligands and synthesis thereof | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-03-05 | — | — | US | disclosed |
| WO-2018106746-A2 | NOVEL CHIRAL DIHYDROBENZOOXAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-06-14 | — | — | WO | disclosed |
| US-20180155375-A1 | NOVEL CHIRAL DIHYDROBENZOOXAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144475-A1 | NOVEL CHIRAL DIHYDROBENZOOXAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF | DCPS, PPIP5K2, PNPO | CYP3A4 1314/4885MAPT 2887/4885NPSR1 2364/4885 |
| US-10544177-B2 | Chiral dihydrobenzooxaphosphole ligands and synthesis thereof | DCPS, PNPO, PPIP5K2 | CYP3A4 1241/4885MAPT 2912/4885NPSR1 2140/4885 |
| US-10221203-B2 | Chiral dihydrobenzooxaphosphole ligands and synthesis thereof | DCPS, PNPO, PPIP5K2 | CYP3A4 1241/4885MAPT 2912/4885NPSR1 2140/4885 |
| US-20180155375-A1 | NOVEL CHIRAL DIHYDROBENZOOXAPHOSPHOLE LIGANDS AND SYNTHESIS THEREOF | DCPS, PPIP5K2, PNPO | CYP3A4 1314/4885MAPT 2887/4885NPSR1 2364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.