Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 7/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20232906 | 1.00 | EPHX1 (0.45) | EPHX1HPGDSTSRECQLPTPN2 | |
| SCHEMBL22280127 | 0.87 | EPHX1 (0.46) | EPHX1HPGDSTSRECQLPTPN2 | |
| SCHEMBL57472 | 0.87 | HPGD (0.47) | EPHX1HPGDSTSRECQLGPR119 | |
| SCHEMBL29055002 | 0.84 | EPHX1 (0.44) | EPHX1HPGDSTSRECQLPTPN2 | |
| SCHEMBL29014961 | 0.82 | RECQL (0.49) | EPHX1HPGDSTSRECQLGPR119 | |
| SCHEMBL2146006 | 0.81 | HPGD (0.47) | EPHX1HPGDSTSRECQLPTPN2 | |
| SCHEMBL31320024 | 0.81 | RECQL (0.48) | EPHX1HPGDSTSRECQLGPR119 | |
| SCHEMBL55991 | 0.81 | HPGD (0.47) | EPHX1HPGDSTSRECQLGPR119 | |
| SCHEMBL29718457 | 0.81 | HPGD (0.47) | EPHX1HPGDSTSRECQLGPR119 | |
| SCHEMBL2146010 | 0.81 | HPGD (0.47) | EPHX1HPGDSTSRECQLPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548480-A1 | COMPOUNDS CONTAINING A SULFONIC GROUP AS KAT INHIBITORS | Epizyme, Inc. (US) | 2019-10-09 | — | — | EP | disclosed |
| WO-2018102419-A1 | COMPOUNDS CONTAINING A SULFONIC GROUP AS KAT INHIBITORS | Epizyme, Inc. (US) | 2018-06-07 | — | — | WO | disclosed |