Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 6/20 | 0.51 |
| ▸ | DRD3 | P35462 | 6/20 | 0.51 |
| ▸ | DRD4 | P21917 | 5/20 | 0.51 |
| ▸ | DRD1 | P21728 | 6/20 | 0.50 |
| ▸ | DRD5 | P21918 | 5/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2204112 | 0.91 | MEN1 (0.62) | MEN1KMT2ADRD2DRD3DRD4 | |
| SCHEMBL2062473 | 0.88 | MEN1 (0.51) | MEN1KMT2ADRD2DRD3DRD4 | |
| SCHEMBL29261689 | 0.82 | AOC3 (0.49) | MEN1KMT2APRMT5WDR77AOC3 | |
| SCHEMBL6071362 | 0.81 | PRMT5 (0.57) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL30021259 | 0.81 | METAP1 (0.50) | DRD2DRD3DRD1DRD5PRMT5 | |
| SCHEMBL8222715 | 0.81 | METAP1 (0.50) | DRD2DRD3DRD1DRD5PRMT5 | |
| SCHEMBL10196887 | 0.80 | GRM5 (0.48) | MEN1KMT2AAOC3HTR2AHTR2C | |
| SCHEMBL17797622 | 0.78 | CASP1 (0.50) | MEN1KMT2AAOC3HSD17B10GRM5 | |
| SCHEMBL31438780 | 0.78 | MEN1 (0.62) | MEN1KMT2ADRD2DRD3DRD4 | |
| SCHEMBL17797550 | 0.78 | SRD5A1 (0.48) | MEN1KMT2APRMT5WDR77AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548479-A1 | ANILINOPYRIMIDINES AS HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS | ARIAD Pharmaceuticals, Inc. (US) | 2019-10-09 | — | — | EP | disclosed |
| WO-2018102366-A1 | ANILINOPYRIMIDINES AS HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) INHIBITORS | ARIAD PHARMACEUTICALS, INC. (US) | 2018-06-07 | — | — | WO | disclosed |