Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.57 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.57 |
| ▸ | DRD3 | P35462 | 5/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 2/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.45 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL471627 | 0.92 | PRMT5 (0.51) | PRMT5WDR77DRD3DRD2DRD4 | |
| SCHEMBL29438671 | 0.92 | PRMT5 (0.51) | PRMT5WDR77DRD3DRD2DRD4 | |
| SCHEMBL19852196 | 0.85 | PRMT5 (0.60) | PRMT5WDR77DRD3DRD2DRD4 | |
| SCHEMBL5946719 | 0.82 | PRMT5 (0.52) | PRMT5WDR77DRD3DRD2DRD4 | |
| SCHEMBL23190427 | 0.82 | PRMT5 (0.52) | PRMT5WDR77DRD3DRD2DRD4 | |
| SCHEMBL20214501 | 0.81 | MEN1 (0.51) | PRMT5WDR77DRD3DRD2DRD4 | |
| SCHEMBL6071228 | 0.80 | PRMT5 (0.55) | PRMT5WDR77DRD3DRD2DRD4 | |
| SCHEMBL24892629 | 0.80 | DRD2 (0.58) | DRD3DRD2DRD4ADAM17DRD1 | |
| SCHEMBL12061308 | 0.80 | HRH3 (0.62) | DRD3DRD2DRD4HSD17B10DRD1 | |
| SCHEMBL21845054 | 0.80 | AOC3 (0.49) | PRMT5WDR77ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060089347-A1 | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses | ELI LILLY AND COMPANY (US) | 2006-04-27 | — | — | US | disclosed |
| EP-1539704-A1 | SUBSTITUTED AZEPINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018432-A1 | SUBSTITUTED AZEPINES AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089347-A1 | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses | HRH3, HRH4, HRH2 | PRMT5 270/4885WDR77 266/4885DRD3 899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.