Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15049593 | 0.86 | SMN1; SMN2 (0.61) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL6224189 | 0.84 | MAPT (0.49) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL5782191 | 0.77 | CA2 (0.45) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL10659467 | 0.77 | MEN1 (0.54) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL5782189 | 0.77 | KMT2A (0.54) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL5858248 | 0.75 | TAS1R3 (0.63) | SMN1; SMN2HPGDALDH1A1GAALMNA | |
| SCHEMBL18803717 | 0.74 | CA2 (0.57) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL4678843 | 0.74 | CA2 (0.70) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL12302109 | 0.74 | CA2 (0.63) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL21078060 | 0.74 | HTT (0.71) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018102358-A1 | METHODS OF TREATING OR PREVENTING COGNITIVE IMPAIRMENT USING INDANE ACETIC ACID DERIVATIVES BASED ON APOE4 GENOTYPE | T3D THERAPEUTICS, INC. (US) | 2018-06-07 | — | — | WO | disclosed |