Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 14/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22907356 | 0.88 | CRBN (0.53) | LRRK2IRAK4CRBNDDB1ALDH1A1 | |
| SCHEMBL20128894 | 0.88 | MAOA (0.57) | LRRK2IRAK4CRBNDDB1ALDH1A1 | |
| SCHEMBL20128892 | 0.87 | IRAK4 (0.52) | LRRK2IRAK4CRBNDDB1ALDH1A1 | |
| SCHEMBL20120588 | 0.87 | CRBN (0.52) | LRRK2IRAK4CRBNDDB1 | |
| SCHEMBL29773803 | 0.87 | CRBN (0.52) | LRRK2IRAK4CRBNDDB1 | |
| SCHEMBL30432431 | 0.86 | CRBN (0.53) | LRRK2IRAK4CRBNDDB1ALDH1A1 | |
| SCHEMBL23705552 | 0.85 | CRBN (0.54) | LRRK2IRAK4CRBNDDB1ALDH1A1 | |
| SCHEMBL20128895 | 0.84 | IRAK4 (0.54) | LRRK2IRAK4CRBNDDB1ALDH1A1 | |
| SCHEMBL23729263 | 0.83 | IRAK4 (0.52) | LRRK2IRAK4CRBNDDB1ALDH1A1 | |
| SCHEMBL23729483 | 0.83 | CRBN (0.54) | LRRK2IRAK4CRBNDDB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3535265-A2 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2019-09-11 | — | — | EP | disclosed |
| WO-2018102067-A2 | TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2018-06-07 | — | — | WO | disclosed |