Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699081 | 1.00 | TRPA1 (0.44) | TRPA1PPARGPPARAALDH1A1MAPT | |
| SCHEMBL27131683 | 1.00 | TRPA1 (0.44) | TRPA1PPARGPPARAALDH1A1MAPT | |
| SCHEMBL27033158 | 1.00 | TRPA1 (0.44) | TRPA1PPARGPPARAALDH1A1MAPT | |
| SCHEMBL21323896 | 1.00 | TRPA1 (0.44) | TRPA1PPARGPPARAALDH1A1MAPT | |
| SCHEMBL17302050 | 0.94 | CNR1 (0.41) | TRPA1PPARGPPARAALDH1A1MAPT | |
| SCHEMBL17302197 | 0.94 | CNR1 (0.41) | TRPA1PPARGPPARAALDH1A1MAPT | |
| SCHEMBL17302118 | 0.89 | S1PR3 (0.48) | TRPA1PPARGPPARAALDH1A1MAPT | |
| SCHEMBL17301887 | 0.86 | S1PR3 (0.46) | TRPA1PPARGPPARAALDH1A1MAPT | |
| SCHEMBL28696589 | 0.85 | CTSK (0.51) | PPARGPPARAMAPTCTSSCTSK | |
| SCHEMBL28598937 | 0.85 | CTSK (0.51) | PPARGPPARAMAPTCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190270726-A1 | PRODUCTS OF CHIRAL SYNTHESIS OF CIS-IMIDAZOLINE COMPOUNDS AND THEIR USE | UNITY BIOTECHNOLOGY, INC. | 2019-09-05 | — | — | US | disclosed |
| US-10329279-B2 | Chiral synthesis method for producing cis-imidazoline compounds for pharmaceutical use | UNITY BIOTECHNOLOGY, INC. (US) | 2019-06-25 | — | — | US | disclosed |
| US-9988368-B1 | Chiral synthesis method for producing cis-imidazoline compounds for pharmaceutical use | UNITY BIOTECHNOLOGY, INC. (US) | 2018-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10329279-B2 | Chiral synthesis method for producing cis-imidazoline compounds for pharmaceutical use | MDM2, CDKN1A, TP53 | TRPA1 2931/4885PPARG 2113/4885PPARA 1538/4885 |
| US-20190270726-A1 | PRODUCTS OF CHIRAL SYNTHESIS OF CIS-IMIDAZOLINE COMPOUNDS AND THEIR USE | MDM2, CDKN1A, TP53 | TRPA1 2728/4885PPARG 2025/4885PPARA 1594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.