Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.70 |
| ▸ | EGFR | P00533 | 9/20 | 0.70 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.70 |
| ▸ | FLT1 | P17948 | 6/20 | 0.70 |
| ▸ | FLT4 | P35916 | 6/20 | 0.70 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | KIF5B | P33176 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2744934 | 0.90 | EGFR (0.57) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL15338410 | 0.87 | EGFR (0.63) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5571167 | 0.87 | TRPA1 (0.57) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL2744926 | 0.86 | KDR (0.53) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL1401640 | 0.83 | KDR (0.65) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5143476 | 0.83 | EGFR (0.56) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL17880567 | 0.83 | KDR (0.58) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL2136908 | 0.83 | EGFR (1.00) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL4420668 | 0.82 | KDR (0.61) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL1401709 | 0.82 | KDR (0.53) | KDREGFRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2018-06-06 | — | — | EP | disclosed |