Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 12/20 | 0.60 |
| ▸ | KDR | P35968 | 5/20 | 0.60 |
| ▸ | FLT3 | P36888 | 4/20 | 0.58 |
| ▸ | EGFR | P00533 | 4/20 | 0.58 |
| ▸ | AXL | P30530 | 2/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | STK25 | O00506 | 1/20 | 0.58 |
| ▸ | CIT | O14578 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | CHUK | O15111 | 1/20 | 0.58 |
| ▸ | MUSK | O15146 | 1/20 | 0.58 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.58 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.58 |
| ▸ | PAK3 | O75914 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371732 | 0.88 | MET (0.80) | METKDRFLT3EGFRAXL | |
| SCHEMBL24444380 | 0.86 | AXL (0.61) | METKDRFLT3EGFRAXL | |
| SCHEMBL20216833 | 0.83 | MET (0.83) | METKDRFLT3EGFRAXL | |
| SCHEMBL21573101 | 0.83 | MET (0.83) | METKDRFLT3EGFRAXL | |
| SCHEMBL15765565 | 0.81 | MET (0.69) | METKDRFLT3EGFRAXL | |
| SCHEMBL20080901 | 0.80 | MET (0.79) | METKDRFLT3EGFRAXL | |
| SCHEMBL29693591 | 0.80 | MET (0.70) | METKDRFLT3EGFRAXL | |
| SCHEMBL24444680 | 0.77 | MET (0.88) | METKDRFLT3EGFRAXL | |
| SCHEMBL371644 | 0.77 | MET (0.87) | METKDRFLT3EGFRAXL | |
| SCHEMBL29693486 | 0.77 | MET (0.87) | METKDRFLT3EGFRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2018-06-06 | — | — | EP | disclosed |