Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | BPTF | Q12830 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17665171 | 0.94 | AKR1C3 (0.45) | AKR1C3HTR7ADRB1RORCNPC1 | |
| SCHEMBL14862125 | 0.81 | AKR1C3 (0.44) | AKR1C3HTR7RORCBPTFMAPT | |
| SCHEMBL24824178 | 0.79 | ADRB1 (0.47) | AKR1C3HTR7ADRB1RAB9AMEN1 | |
| SCHEMBL20510814 | 0.77 | AKR1C3 (0.44) | AKR1C3HTR7ADRB1NPC1RAB9A | |
| SCHEMBL20217190 | 0.75 | ADRB1 (0.47) | AKR1C3ADRB1RORCNPC1RAB9A | |
| SCHEMBL31453263 | 0.75 | GAA (0.45) | AKR1C3HTR7ADRB1NPC1RAB9A | |
| SCHEMBL20510583 | 0.74 | BPTF (0.66) | ADRB1MEN1KMT2ABPTF | |
| SCHEMBL28956356 | 0.74 | BPTF (0.66) | ADRB1MEN1KMT2ABPTF | |
| SCHEMBL22466116 | 0.74 | MAPT (0.44) | RORCNPC1RAB9ATP53MAPK1 | |
| SCHEMBL24824179 | 0.74 | RORC (0.38) | RORCBPTFMAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |