Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | TTK | P33981 | 4/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | SLC5A7 | Q9GZV3 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217573 | 0.91 | CYP3A4 (0.41) | CYP3A4TTKKCNH2AURKBINCENP | |
| SCHEMBL20217391 | 0.91 | F10 (0.44) | CYP3A4TTKHRH1CCR3KCNH2 | |
| SCHEMBL20217252 | 0.91 | CYP3A4 (0.41) | CYP3A4TTKAURKBINCENPF10 | |
| SCHEMBL20217221 | 0.89 | TTK (0.51) | CYP3A4TTKAURKBINCENPF10 | |
| SCHEMBL20217594 | 0.88 | F10 (0.43) | CYP3A4TTKHRH1CCR3KCNH2 | |
| SCHEMBL20217751 | 0.85 | CYP3A4 (0.55) | CYP3A4TTKAURKBINCENPF10 | |
| SCHEMBL20217290 | 0.85 | ALDH1A1 (0.49) | CYP3A4TTKAURKBINCENPF10 | |
| SCHEMBL20217747 | 0.83 | CYP3A4 (0.47) | CYP3A4TTKAURKBINCENPF10 | |
| SCHEMBL20217537 | 0.83 | KMT2A (0.43) | CYP3A4TTKAURKBINCENPF10 | |
| SCHEMBL20217315 | 0.82 | CYP3A4 (0.52) | CYP3A4TTKAURKBINCENPF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |