Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217381 | 0.87 | HDAC1 (0.31) | — | |
| SCHEMBL20217356 | 0.82 | HDAC8 (0.43) | MAPTKDM4ELMNAALDH1A1MAPK1 | |
| SCHEMBL20217314 | 0.80 | IP6K1 (0.34) | MAPTKDM4ELMNAALDH1A1HPGD | |
| SCHEMBL14418345 | 0.79 | MAPT (0.59) | MAPTBTKLRRK2ALDH1A1 | |
| SCHEMBL14565367 | 0.79 | MAPT (0.59) | MAPTBTKLRRK2ALDH1A1 | |
| SCHEMBL10133315 | 0.79 | MAPT (0.59) | MAPTBTKLRRK2ALDH1A1 | |
| SCHEMBL20217237 | 0.75 | HDAC3 (0.38) | MAPTKDM4ELMNALRRK2ALDH1A1 | |
| SCHEMBL20217281 | 0.73 | TRPV1 (0.32) | — | |
| SCHEMBL21254717 | 0.73 | MAPT (0.53) | MAPTKDM4ELMNAALDH1A1MAPK1 | |
| SCHEMBL20217239 | 0.71 | F10 (0.41) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |