Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 4/20 | 0.39 |
| ▸ | NSD2 | O96028 | 2/20 | 0.38 |
| ▸ | SETD2 | Q9BYW2 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217332 | 1.00 | TRPM8 (0.43) | TRPM8MEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL20217145 | 0.89 | CYP3A4 (0.47) | TRPM8MEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL20217368 | 0.88 | CYP3A4 (0.46) | TRPM8MEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL20217337 | 0.87 | TRPM8 (0.33) | TRPM8AKT1KITLRRK2 | |
| SCHEMBL20217267 | 0.84 | MEN1 (0.56) | MEN1ALDH1A1MAPK1KMT2AAKT1 | |
| SCHEMBL20217157 | 0.83 | MEN1 (0.54) | MEN1ALDH1A1MAPK1KMT2AAKT1 | |
| SCHEMBL20217642 | 0.81 | CYP3A4 (0.44) | MAPK1CYP3A4TTKAURKBINCENP | |
| SCHEMBL20217242 | 0.80 | AKT1 (0.41) | MEN1ALDH1A1MAPK1KMT2AAKT1 | |
| SCHEMBL20217349 | 0.79 | CYP3A4 (0.50) | TRPM8MEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL20217601 | 0.79 | CYP3A4 (0.41) | TRPM8MEN1ALDH1A1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |