Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.47 |
| ▸ | TTK | P33981 | 6/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.47 |
| ▸ | INCENP | Q9NQS7 | 6/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217446 | 0.87 | CYP3A4 (0.53) | CYP3A4TTKAURKBINCENPWDR5 | |
| SCHEMBL20217579 | 0.84 | CYP3A4 (0.65) | CYP3A4TTKAURKBINCENPWDR5 | |
| SCHEMBL20217371 | 0.82 | CYP3A4 (0.42) | CYP3A4TTKAURKBINCENPWDR5 | |
| SCHEMBL20217484 | 0.81 | CYP3A4 (0.65) | CYP3A4TTKAURKBINCENPSLC6A9 | |
| SCHEMBL20217348 | 0.81 | CYP3A4 (0.47) | CYP3A4TTKAURKBINCENPSLC6A9 | |
| SCHEMBL20217777 | 0.81 | KMT2A (0.49) | CYP3A4MAPK1 | |
| SCHEMBL20217912 | 0.81 | CYP3A4 (0.43) | CYP3A4TTKAURKBINCENPWDR5 | |
| SCHEMBL16292275 | 0.80 | TTK (0.73) | CYP3A4TTKAURKBINCENP | |
| SCHEMBL14873458 | 0.80 | TTK (0.73) | CYP3A4TTKAURKBINCENP | |
| SCHEMBL20217236 | 0.80 | HDAC3 (0.44) | HDAC6HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |