Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.65 |
| ▸ | TTK | P33981 | 7/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.65 |
| ▸ | INCENP | Q9NQS7 | 7/20 | 0.65 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 4/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217579 | 0.97 | CYP3A4 (0.65) | CYP3A4TTKAURKBINCENPSLC6A9 | |
| SCHEMBL20217446 | 0.89 | CYP3A4 (0.53) | CYP3A4TTKAURKBINCENPTRPM8 | |
| SCHEMBL20217846 | 0.86 | CYP3A4 (0.49) | CYP3A4TTKAURKBINCENPTRPM8 | |
| SCHEMBL20217549 | 0.85 | CYP3A4 (0.49) | CYP3A4TTKAURKBINCENPMEN1 | |
| SCHEMBL20217496 | 0.82 | CYP3A4 (0.62) | CYP3A4TTKAURKBINCENPHDAC6 | |
| SCHEMBL20217662 | 0.82 | CYP3A4 (0.47) | CYP3A4TTKAURKBINCENPTRPM8 | |
| SCHEMBL20217641 | 0.81 | CYP3A4 (0.47) | CYP3A4TTKAURKBINCENPSLC6A9 | |
| SCHEMBL20217348 | 0.81 | CYP3A4 (0.47) | CYP3A4TTKAURKBINCENPSLC6A9 | |
| SCHEMBL20217458 | 0.81 | CYP3A4 (0.50) | CYP3A4TTKAURKBINCENPTRPM8 | |
| SCHEMBL20217912 | 0.81 | CYP3A4 (0.43) | CYP3A4TTKAURKBINCENPSLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |