Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | TTK | P33981 | 5/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.47 |
| ▸ | INCENP | Q9NQS7 | 5/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 11/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217284 | 0.89 | CHRM2 (0.47) | CHRM2F2F10PRSS1MCHR1 | |
| SCHEMBL20217446 | 0.85 | CYP3A4 (0.53) | CYP3A4TTKAURKBINCENPF2 | |
| SCHEMBL20217579 | 0.84 | CYP3A4 (0.65) | CYP3A4TTKAURKBINCENPSLC6A9 | |
| SCHEMBL20217641 | 0.81 | CYP3A4 (0.47) | CYP3A4TTKAURKBINCENPF2 | |
| SCHEMBL20217484 | 0.81 | CYP3A4 (0.65) | CYP3A4TTKAURKBINCENPSLC6A9 | |
| SCHEMBL20217912 | 0.79 | CYP3A4 (0.43) | CYP3A4TTKAURKBINCENPSLC6A9 | |
| SCHEMBL20217549 | 0.77 | CYP3A4 (0.49) | CYP3A4TTKAURKBINCENP | |
| SCHEMBL20217478 | 0.76 | LMNA (0.42) | CYP3A4TTKAURKBINCENPCHRM2 | |
| SCHEMBL20217312 | 0.76 | CYP3A4 (0.40) | CYP3A4TTKAURKBINCENPCHRM2 | |
| SCHEMBL20217734 | 0.75 | CYP3A4 (0.43) | CYP3A4TTKAURKBINCENPCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |