Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20217305 | 0.81 | HSD17B10 (0.49) | HSD17B10PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20217479 | 0.78 | MAPK1 (0.43) | HSD17B10MAOAHPGDMEN1KMT2A | |
| SCHEMBL20217667 | 0.77 | CNR2 (0.42) | HSD17B10HPGDKMT2AMAPK1KLKB1 | |
| SCHEMBL20217756 | 0.77 | EPHX2 (0.41) | KCNH2EPHX2KMT2AMAPK1 | |
| SCHEMBL20217582 | 0.74 | HRH3 (0.39) | KCNH2OPRM1OPRD1MEN1KMT2A | |
| SCHEMBL20217393 | 0.72 | ALDH1A1 (0.57) | HSD17B10MAOAHPGDMEN1KMT2A | |
| SCHEMBL20217247 | 0.72 | KMT2A (0.48) | HSD17B10HPGDMEN1KMT2A | |
| SCHEMBL20217390 | 0.72 | TTK (0.63) | HSD17B10OPRK1KCNH2OPRM1MEN1 | |
| SCHEMBL20217541 | 0.72 | CYP3A4 (0.49) | HSD17B10OPRK1KCNH2OPRM1MEN1 | |
| SCHEMBL20217365 | 0.72 | RXFP1 (0.44) | MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2766352-B1 | INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIV HEALTH NETWORK UHN (CA) | 2018-06-06 | — | — | EP | disclosed |