Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12017402 | 0.83 | APP (0.49) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL12017474 | 0.74 | APP (0.37) | MAPTMEN1KMT2ACYP1A2APP | |
| SCHEMBL1243217 | 0.74 | RAB9A (0.47) | MEN1KMT2AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL12987122 | 0.72 | HTT (0.35) | MAPTSMN1; SMN2HTTTP53HPGD | |
| SCHEMBL12017485 | 0.72 | MCL1 (0.52) | GAAALDH1A1HTTTSHR | |
| SCHEMBL12987482 | 0.70 | MEN1 (0.35) | MAPTMEN1KMT2AALDH1A1MAPK14 | |
| SCHEMBL3338194 | 0.69 | APP (0.40) | MAPTGAAMEN1KMT2ARECQL | |
| SCHEMBL8970984 | 0.69 | MAPK10 (0.55) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL10544006 | 0.68 | CYSLTR1 (0.51) | — | |
| SCHEMBL19283174 | 0.67 | TAAR1 (0.50) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269763-A1 | CRTH2 receptor ligands for medicinal uses | 7TM PHARMA A/S (DK) | 2011-11-03 | — | — | US | disclosed |
| US-8022063-B2 | CRTH2 receptor ligands for medicinal uses | 7TM PHARMA A/S (DK) | 2011-09-20 | — | — | US | disclosed |
| EP-2336113-A1 | CRTH2 Receptor Ligands for Medical Use | 7TM Pharma A/S (DK) | 2011-06-22 | — | — | EP | disclosed |
| US-20090099189-A1 | CRTH2 Receptor Ligands For Medicinal Uses | 7TM PHARMA A/S (DK) | 2009-04-16 | — | — | US | disclosed |
| US-20080312220-A1 | Oxadiazole Derivatives with Crth2 Receptor Activity | 7TM PHARMA A/S (DK) | 2008-12-18 | — | — | US | disclosed |
| EP-1960376-A1 | OXADIAZOLE DERIVATIVES WITH CRTH2 RECEPTOR ACTIVITY | 7TM Pharma A/S (DK) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007062677-A1 | THIAZOLYL- AND PYRIMIDINYL-ACETIC ACIDS AND THEIR USE AS CRTH2 RECEPTOR LIGANDS | 7TM PHARMA A/S (DK) | 2007-06-07 | — | — | WO | disclosed |
| WO-2007062678-A1 | PHENOXYACETIC ACID DERIVATIVES AS CRTH2 RECEPTOR LIGANDS | 7TM PHARMA A/S (DK) | 2007-06-07 | — | — | WO | disclosed |
| WO-2007062773-A1 | OXADIAZOLE DERIVATIVES WITH CRTH2 RECEPTOR ACTIVITY | 7TM PHARMA A/S (DK) | 2007-06-07 | — | — | WO | disclosed |
| EP-1758579-A1 | CRTH2 RECEPTOR LIGANDS FOR MEDICINAL USES | 7TM Pharma A/S (DK) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005115382-A1 | CRTH2 RECEPTOR LIGANDS FOR MEDICINAL USES | 7TM PHARMA A/S (DK) | 2005-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312220-A1 | Oxadiazole Derivatives with Crth2 Receptor Activity | HRH2, HRH1, HRH3 | AURKA 3722/4885MAPT 4758/4885GAA 4659/4885 |
| US-20090099189-A1 | CRTH2 Receptor Ligands For Medicinal Uses | HRH1, HRH2, HRH3 | AURKA 4533/4885MAPT 4672/4885GAA 4427/4885 |
| US-20110269763-A1 | CRTH2 receptor ligands for medicinal uses | HRH1, HRH2, HRH4 | AURKA 4336/4885MAPT 4755/4885GAA 4385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.