Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2022594 | 0.84 | ADORA2A (0.47) | ADORA2AADORA1ADORA3ALDH1A1MAPT | |
| SCHEMBL2024778 | 0.84 | ADORA2A (0.58) | ADORA2AADORA1ADORA3ALDH1A1TLR8 | |
| SCHEMBL2027751 | 0.80 | ADORA2A (0.59) | ADORA2AADORA1ADORA3ALDH1A1MAPT | |
| SCHEMBL2023069 | 0.80 | APP (0.43) | ADORA2AADORA1 | |
| SCHEMBL2023701 | 0.79 | HSP90AA1 (0.51) | ADORA2AADORA1ADORA3 | |
| SCHEMBL2018800 | 0.76 | DHFR (0.46) | ADORA2AADORA1ADORA3ALDH1A1MAPT | |
| SCHEMBL2815835 | 0.73 | ADORA2A (0.90) | ADORA2AADORA1 | |
| SCHEMBL2947512 | 0.72 | MAPT (0.62) | ADORA2AADORA1ALDH1A1MAPTTLR8 | |
| SCHEMBL28186684 | 0.72 | TLR8 (0.61) | ADORA2AADORA1ALDH1A1MAPTTLR8 | |
| SCHEMBL2024812 | 0.72 | ADORA2A (0.46) | ADORA2AADORA1ADORA3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | ARQULE, INC. (US) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | MKI67, TP53, THPO | ADORA2A 985/4885ADORA1 2652/4885ADORA3 1835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.