Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2023701 | 0.84 | HSP90AA1 (0.51) | ADORA2AADORA1ADORA3 | |
| SCHEMBL2021909 | 0.80 | ADORA2A (0.61) | ADORA2AADORA1ADORA3TLR9TLR7 | |
| SCHEMBL2024812 | 0.80 | ADORA2A (0.46) | ADORA2AADORA1ADORA3ALDH1A1KDM4E | |
| SCHEMBL2025321 | 0.79 | ALDH1A1 (0.51) | ADORA2AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL2818141 | 0.76 | ADORA2A (0.69) | ADORA2AADORA1ADORA3TLR9TLR7 | |
| SCHEMBL2018893 | 0.72 | LMNA (0.42) | ADORA2AADORA1ADORA3TSHRTP53 | |
| SCHEMBL2022715 | 0.70 | TLR8 (0.45) | ADORA2AADORA1ADORA3HSD17B10ALDH1A1 | |
| SCHEMBL12306207 | 0.70 | HSP90AA1 (0.59) | ADORA2AADORA1ADORA3TLR9TLR7 | |
| SCHEMBL2018492 | 0.69 | ADORA2A (0.51) | ADORA2ATSHRHSD17B10ALDH1A1MAPK1 | |
| SCHEMBL2019577 | 0.69 | LMNA (0.43) | ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329705-B2 | Substituted triazolo-pyrazine compounds | ARQULE, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | ARQULE, INC. (US) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | MKI67, TP53, THPO | ADORA2A 985/4885ADORA1 2652/4885ADORA3 1835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.