Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20413292 | 0.88 | TAS1R3 (0.39) | KCNH2TLR7TLR8 | |
| SCHEMBL23472692 | 0.87 | KCNH2 (0.34) | KCNH2TLR7TLR8CHRM2CHRM1 | |
| SCHEMBL23472282 | 0.85 | TLR7 (0.42) | KCNH2TLR7TLR8 | |
| SCHEMBL20413288 | 0.84 | HPGD (0.39) | KCNH2TLR7TLR8 | |
| SCHEMBL20413290 | 0.82 | TAS1R3 (0.40) | TLR7TLR8 | |
| SCHEMBL20386702 | 0.80 | TLR7 (0.46) | KCNH2TLR7TLR8 | |
| SCHEMBL23472236 | 0.79 | KCNH2 (0.43) | KCNH2TLR7TLR8 | |
| SCHEMBL15470269 | 0.79 | TLR7 (0.44) | KCNH2TLR7TLR8 | |
| SCHEMBL20219720 | 0.76 | TLR7 (0.46) | KCNH2TLR7TLR8 | |
| SCHEMBL15470255 | 0.75 | TLR7 (0.42) | KCNH2TLR7TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330257-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | Janssen Sciences Ireland UC (IE) | 2018-06-06 | — | — | EP | disclosed |