Aconitic Acid

Aconitic Acid

SCHEMBL2022211

O=C(O)/C=C(/CC(=O)O)C(=O)O.O=C(O)/C=C(/CC(=O)O)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 1.00
KDM4E B2RXH2 1/20 1.00
LDHA P00338 1/20 0.42
SRR Q9GZT4 1/20 0.42
ALOX15 P16050 2/20 0.41
HSD17B10 Q99714 1/20 0.41
CPB1 P15086 1/20 0.41
CYP2C19 P33261 1/20 0.39
RECQL P46063 1/20 0.33
ABAT P80404 1/20 0.31
GABRR1 P24046 2/20 0.31
GABRR2 P28476 2/20 0.31
BLM P54132 2/20 0.31
GABRR3 A8MPY1 1/20 0.31
LMNA P02545 1/20 0.31
APEX1 P27695 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
ALDH1A1 P00352 1/20 0.30
CYP2D6 P10635 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aconitic Acid SCHEMBL1275978 1.00 TSHR (1.00) TSHRKDM4ELDHASRRALOX15
Aconitic Acid SCHEMBL16935 1.00 TSHR (1.00) TSHRKDM4ELDHASRRALOX15
Aconitic Acid SCHEMBL219037 1.00 TSHR (1.00) TSHRKDM4ELDHASRRALOX15
Aconitic Acid SCHEMBL22334 1.00 TSHR (1.00) TSHRKDM4ELDHASRRALOX15
Aconitic Acid SCHEMBL1289876 1.00 TSHR (1.00) TSHRKDM4ELDHASRRALOX15
Aconitic Acid SCHEMBL29245497 0.97 TSHR (0.95) TSHRKDM4ELDHASRRALOX15
Aconitic Acid SCHEMBL9394649 0.97 TSHR (0.95) TSHRKDM4ELDHASRRALOX15
Aconitic Acid SCHEMBL27871922 0.97 TSHR (0.95) TSHRKDM4ELDHASRRALOX15
Aconitic Acid SCHEMBL30275008 0.97 TSHR (0.95) TSHRKDM4ELDHASRRALOX15
Aconitic Acid SCHEMBL27690462 0.97 TSHR (0.95) TSHRKDM4ELDHASRRALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110160036-A1 VALVE METAL OXIDE FORMULATION H.C. STARCK GMBH (DE) 2011-06-30 US disclosed