Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20227005 | 0.85 | POLB (0.42) | POLBGSTP1MAOAMAOBUSP2 | |
| SCHEMBL20226976 | 0.82 | POLB (0.43) | POLBGSTP1MAOAMAOBUSP2 | |
| SCHEMBL23512775 | 0.81 | POLB (0.56) | RHEBPOLBGSTP1USP2ALDH1A1 | |
| SCHEMBL20227002 | 0.78 | CCNB2 (0.48) | POLBGSTP1MAOAMAOBUSP2 | |
| SCHEMBL20218243 | 0.71 | TEAD4 (0.42) | POLBGSTP1MAOAMAOBUSP2 | |
| SCHEMBL71120 | 0.70 | GSTP1 (0.44) | RHEBPOLBGSTP1LMNANSD2 | |
| SCHEMBL20226995 | 0.68 | POLB (0.47) | POLBMAOAMAOBUSP2ALDH1A1 | |
| SCHEMBL27431645 | 0.67 | RHEB (0.50) | RHEBMAOBLMNAHPGD | |
| SCHEMBL7622844 | 0.66 | KDM4E (0.48) | POLBGSTP1USP2ALDH1A1LMNA | |
| SCHEMBL2115663 | 0.66 | LMNA (0.50) | POLBGSTP1MAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018102634-A1 | TRICYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-06-07 | — | — | WO | disclosed |