Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD4 | Q15561 | 4/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | CREB1 | P16220 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16921607 | 0.87 | LMNA (0.44) | DAOCREB1LMNAGAAGSTP1 | |
| SCHEMBL10290054 | 0.87 | LMNA (0.41) | DAOCREB1LMNAGAAGSTP1 | |
| SCHEMBL7622844 | 0.82 | KDM4E (0.48) | TEAD4DAOCREB1LMNAGAA | |
| SCHEMBL2115663 | 0.82 | LMNA (0.50) | CREB1LMNAGAAGSTP1MEN1 | |
| SCHEMBL22997609 | 0.81 | LMNA (0.56) | TEAD4DAOCREB1LMNAGAA | |
| SCHEMBL31281619 | 0.81 | THRA (0.44) | TEAD4DAOCREB1LMNAGAA | |
| SCHEMBL17402173 | 0.81 | ABCG2 (0.39) | CREB1LMNAGAAGSTP1MEN1 | |
| SCHEMBL22872659 | 0.80 | TEAD4 (0.43) | TEAD4DAOCREB1LMNAGAA | |
| SCHEMBL11092303 | 0.80 | CREB1 (0.47) | TEAD4DAOCREB1LMNAGAA | |
| SCHEMBL752436 | 0.80 | LMNA (0.38) | CREB1LMNAGAAGSTP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3330272-B1 | FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3330272-A1 | FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-06-06 | — | — | EP | disclosed |