SCHEMBL2022977

SCHEMBL2022977

O=C(O)CCBr.O=C(O)CCBr.O=C(O)CCBr.O=C(O)CCBr.O=C1C=CC(=O)N1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3A P49840 1/20 0.48
GSK3B P49841 1/20 0.48
CCR6 P51684 1/20 0.48
PTGS1 P23219 4/20 0.33
PTGS2 P35354 4/20 0.33
LMNA P02545 2/20 0.33
ALKBH5 Q6P6C2 1/20 0.33
SUCNR1 Q9BXA5 1/20 0.33
EGLN1 Q9GZT9 1/20 0.33
TSHR P16473 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
F13A1 P00488 3/20 0.31
APEX1 P27695 1/20 0.31
KEAP1 Q14145 1/20 0.31
SLC22A6 Q4U2R8 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2027194 1.00 GSK3A (0.48) GSK3AGSK3BCCR6PTGS1PTGS2
Succinic Acid SCHEMBL4127642 0.86 GSK3A (0.58) GSK3AGSK3BCCR6PTGS1PTGS2
Glutarate SCHEMBL28390952 0.82 GSK3A (0.52) GSK3AGSK3BCCR6PTGS1PTGS2
Butyric Acid SCHEMBL714988 0.78 FFAR3 (0.56) GSK3AGSK3BCCR6LMNATSHR
Glycolic Acid SCHEMBL29471409 0.77 GSK3A (0.58) GSK3AGSK3BCCR6TSHR
Nitrilotriacetic Acid SCHEMBL6684737 0.76 GSK3A (0.50) GSK3AGSK3BCCR6LMNATSHR
Bicarbonate SCHEMBL5071661 0.75 GSK3A (0.73) GSK3AGSK3BCCR6SMN1; SMN2HSD17B10
SCHEMBL28472 0.75
Valeric Acid SCHEMBL28168375 0.75 AKR1B1 (0.52) GSK3AGSK3BCCR6PTGS1LMNA
Thioglycolic Acid SCHEMBL2267919 0.75 GSK3A (0.55) GSK3AGSK3BCCR6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11819531-B2 Multifunctional zwitterionic polymer conjugates KODIAK SCIENCES INC. (US) 2023-11-21 US disclosed
EP-3659591-B1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES KODIAK SCIENCES INC (US) 2023-10-25 EP disclosed
US-20230277616-A9 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES KODIAK SCIENCES INC. 2023-09-07 US disclosed
EP-4029510-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS Kodiak Sciences Inc. (US) 2022-07-20 EP disclosed
EP-3549963-B1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS KODIAK SCIENCES INC (US) 2022-01-12 EP disclosed
US-20200171179-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS KODIAK SCIENCES INC. 2020-06-04 US disclosed
EP-3659591-A1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES Kodiak Sciences Inc. (US) 2020-06-03 EP disclosed
EP-3254678-B1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES KODIAK SCIENCES INC (US) 2020-02-19 EP disclosed
EP-3549963-A2 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS Kodiak Sciences Inc. (US) 2019-10-09 EP disclosed
EP-2558538-B1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS KODIAK SCIENCES INC (US) 2019-07-03 EP disclosed
EP-2512462-B1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES KODIAK SCIENCES INC (US) 2017-08-23 EP disclosed
US-20160287715-A1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES KODIAK SCIENCES INC (US) 2016-10-06 US disclosed
EP-2558538-A2 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS Oligasis (US) 2013-02-20 EP disclosed
EP-2512462-A1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES Oligasis (US) 2012-10-24 EP disclosed
WO-2011130694-A2 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS OLIGASIS (US) 2011-10-20 WO disclosed
WO-2011075736-A1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES OLIGASIS (US) 2011-06-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230277616-A9 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES PHOSPHO1, MSN, ZW10 GSK3A 2561/4885GSK3B 2852/4885CCR6 426/4885
US-20160287715-A1 MULTIFUNCTIONAL ZWITTERIONIC POLYMER CONJUGATES PHOSPHO1, MSN, ZW10 GSK3A 2561/4885GSK3B 2852/4885CCR6 426/4885
US-20200171179-A1 HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS ACP1, PHOSPHO1, PARG GSK3A 1162/4885GSK3B 1763/4885CCR6 812/4885
US-11819531-B2 Multifunctional zwitterionic polymer conjugates PHOSPHO1, MSN, ZW10 GSK3A 2561/4885GSK3B 2852/4885CCR6 426/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.