ZW10 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

	Compound	Confidence	Supporting neighbours

Clinical trials — most relevant to ZW10 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase I Study to Assess the Safety, Pharmacokinetics, & Pharmacodynamics of GSK923295 in Subjects w/ Refractory Cancer	PHASE1	COMPLETED
Breakpoint Analysis of de Novo Apparently Balanced Chromosomal Translocations	EARLY_PHASE1	COMPLETED
Whole-genome Sequencing Study in Patients With Diminished Ovarian Reserve	nan	UNKNOWN
Characterization of WAGR Syndrome and Other Chromosome 11 Gene Deletions	nan	COMPLETED
Better Delineation of CDK13 Related Phenotype and Epigenetic Signature.	nan	UNKNOWN
Importance of the Microtubule Cytoskeleton in Oocyte Competence	nan	COMPLETED
Post Market Surveillance & Post Market Clinical Follow up, International, Medical Registry to Confirm the Safety and the Performance of the Anecova Intra Uterine Culture Device	nan	WITHDRAWN
Maternal Genes and Epimutations: Beckwith-Wiedemann Syndrome & Reproductive Risks	nan	RECRUITING
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan	nan	ENROLLING_BY_INVITATION
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Result Of Karyotyping in Pediatric Patients With Congenital Anomalies and Developmental Delay	nan	NOT_YET_RECRUITING
Uncovering the Etiologies of Non-immune Hydrops Fetalis	nan	ENROLLING_BY_INVITATION
Whole Exome Sequencing in Prenatal Diagnosis of Agenesis of the Corpus Callosum	nan	COMPLETED
The Sequencing for Detection in Congenital Heart Disease (SD-CHD) Study	nan	RECRUITING
Human MATER and Idiopathic Infertility	nan	COMPLETED
Target of Suv420h1/2 in Hepatocytes	nan	RECRUITING
PCM1-JAK2 in Therapy Related Neoplasms	nan	UNKNOWN
Validation of Optical Genome Mapping for the Identification of Constitutional Genomic Variants in a Postnatal Cohort	nan	UNKNOWN
Identification of Genetic Variants Associated With Unexpected Infant Death Syndrome	nan	RECRUITING
Clinical Utility of Prenatal Whole Exome Sequencing	nan	COMPLETED
Genomic Medicine for Ill Neonates and Infants (The GEMINI Study)	nan	COMPLETED
North Carolina Newborn Exome Sequencing for Universal Screening	nan	COMPLETED
Genetic Study of Patients With Primary Ciliary Dyskinesia	nan	COMPLETED
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms	nan	UNKNOWN
Molecular Associations With Reproductive Failure	nan	COMPLETED
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility	nan	RECRUITING
Chromosome 9 P Minus Syndrome	nan	RECRUITING
Genomic Study of Congenital Malformation	nan	UNKNOWN
Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a ZW10 binder may also engage these)

Protein	Name	Similarity
Q5RFM4	—	1.000	Q5RFM4 →
Q4V8C2	—	1.000	Q4V8C2 →
O54692	—	1.000	O54692 →
Q6NUQ1	—	0.993	Q6NUQ1 →
P97878	—	0.988	P97878 →
Q8BZ36	—	0.988	Q8BZ36 →
O54921	—	0.986	O54921 →
Q9D4H1	—	0.980	Q9D4H1 →
Q9LTB0	—	0.979	Q9LTB0 →
COG1	Conserved oligomeric Golgi complex subunit 1	0.979	landscape →
Q95JW3	—	0.979	Q95JW3 →
Q96KP1	—	0.977	Q96KP1 →
Q9JMK8	—	0.977	Q9JMK8 →
COG2	Conserved oligomeric Golgi complex subunit 2	0.976	landscape →
O00471	—	0.976	O00471 →
Q5R7R6	—	0.976	Q5R7R6 →
Q3TPX4	—	0.975	Q3TPX4 →
Q08CZ0	—	0.974	Q08CZ0 →
Q29RB1	—	0.974	Q29RB1 →
P48553	—	0.974	P48553 →
Q5SPW0	—	0.973	Q5SPW0 →
Q9Z160	—	0.973	Q9Z160 →
Q6NXY1	—	0.973	Q6NXY1 →
Q96DN5	—	0.973	Q96DN5 →
F4I4B6	—	0.972	F4I4B6 →
Q29RL0	—	0.972	Q29RL0 →
X5JB51	—	0.972	X5JB51 →
COG4	Conserved oligomeric Golgi complex subunit 4	0.972	landscape →
Q505L3	—	0.972	Q505L3 →
Q8CEC0	—	0.972	Q8CEC0 →