SCHEMBL202305

SCHEMBL202305

C#Cc1ccc(C(F)(F)F)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 1/20 0.55
KIF11 P52732 6/20 0.52
HDAC8 Q9BY41 2/20 0.46
ALDH1A1 P00352 1/20 0.43
TSHR P16473 1/20 0.43
PYCR1 P32322 1/20 0.41
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41
ORAI1 Q96D31 1/20 0.41
ORAI2 Q96SN7 1/20 0.41
ORAI3 Q9BRQ5 1/20 0.41
TRPV6 Q9H1D0 1/20 0.41
MGLL Q99685 1/20 0.41
TAAR1 Q96RJ0 1/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA4 P22748 1/20 0.38
CA9 Q16790 1/20 0.38
CA14 Q9ULX7 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL28242095 0.97 PTPN1 (0.53) PTPN1KIF11HDAC8ALDH1A1TSHR
SCHEMBL5179886 0.80 PTPN1 (0.52) PTPN1KIF11HDAC8CA12CA1
Trifluoromethylbenzene SCHEMBL28267145 0.80 TSHR (0.58) PTPN1KIF11HDAC8ALDH1A1TSHR
SCHEMBL23059787 0.80 PTPN1 (0.40) PTPN1KIF11ALDH1A1TSHRPYCR1
SCHEMBL28558077 0.78 PTPN1 (0.48) PTPN1KIF11HDAC8CA12CA1
SCHEMBL16747679 0.78 KIF11 (0.56) KIF11ALDH1A1TSHRCES2CES1
SCHEMBL14998069 0.78 KIF11 (0.56) KIF11ALDH1A1TSHRCES2CES1
SCHEMBL2862671 0.78 KIF11 (0.56) KIF11ALDH1A1TSHRCES2CES1
SCHEMBL450726 0.78 PTPN1 (0.48) PTPN1KIF11HDAC8CA12CA1
SCHEMBL24244657 0.77 PTPN1 (0.48) PTPN1KIF11HDAC8CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 959 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119350569-A Synthesis method of trivalent rhodium covalent organic framework catalyst 沈阳师范大学 2025-01-24 CN claimed
US-12170189-B2 Coating apparatus and coating method JIANGSU FAVORED NANOTECHNOLOGY CO., LTD. (CN) 2024-12-17 US claimed
CN-115872993-B Method for continuously synthesizing piperidone by photoinduction 南京工业大学 2024-12-10 CN claimed
CN-117646229-A Method for preparing ammonia by catalyzing NO through ultra-small copper nanoclusters 广州惠清环保技术有限公司 2024-03-05 CN claimed
CN-117624520-A Trifluoromethyl modified pyrenyl covalent organic framework material, and preparation method and application thereof 中国石油大学(华东) 2024-03-01 CN claimed
CN-116606481-B Thermal insulation aerogel composite and its use in sensor housings 安徽省安瑞机电科技有限公司 2023-11-28 CN claimed
US-11814462-B2 Functionalized cyclic polymers and methods of preparing same UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2023-11-14 US claimed
CN-116874421-A Method for synthesizing 1,1' -biisoquinoline derivative from 2, 2-dimethyl-4, 5-diaryl-2H-imidazole 桂林理工大学 2023-10-13 CN claimed
CN-116747905-A Preparation of ultra-small palladium nanocluster and application thereof in eliminating nitrate nitrogen in wastewater 广州惠清环保技术有限公司 2023-09-15 CN claimed
CN-116606481-A Thermal insulation aerogel composite and its use in sensor housings 安徽省安瑞机电科技有限公司 2023-08-18 CN claimed
CN-103467282-A Synthesis method of polysubstitution naphthol and derivative of polysubstitution naphthol NANJING UNIVERSITY OF TECHNOLOGY 2013-12-25 CN claimed
EP-2207550-B1 TETRAHYDROQUINOLINE DERIVATIVES FOR TREATING POST-TRAUMATIC STRESS DISORDERS ACTELION PHARMACEUTICALS LTD (CH) 2013-12-11 EP claimed
EP-2013171-B1 PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER S DISEASE MERCK SHARP & DOHME (GB) 2013-05-15 EP claimed
WO-2012149644-A1 NOVEL AGONISTS AND ANTAGONISTS OF THE UROTENSINERGIC SYSTEM INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CA) 2012-11-08 WO claimed
EP-2215050-B1 MANUFACTURING METHOD OF 2-HYDROXY-5-PHENYLALKYLAMINOBENZOIC ACID DERIVATIVES AND THEIR SALTS NEUROTECH PHARMACEUTICALS CO LTD (KR) 2012-06-27 EP claimed
EP-2108012-A2 SUBSTITUTED N-(4-CYANO-1H-PYRAZOL-3-YL)METHYLAMINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF Sanofi-Aventis (FR) 2009-10-14 EP claimed
EP-1611088-B1 HYDROXAMATES AS THERAPEUTIC AGENTS PHARMACYCLICS INC (US) 2009-06-17 EP claimed
EP-1567493-B1 PHENYL SUBSTITUTED PIPERIDINE COMPOUNDS FOR USE AS PPAR ACTIVATORS PFIZER PROD INC (US) 2009-03-18 EP claimed
WO-2008099076-A2 SUBSTITUTED N-(4-CYANO-1H-PYRAZOL-3-YL)METHYLAMINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2008-08-21 WO claimed
EP-0328830-B1 4-Heteropentacyclic-4- N-(phenyl)amido piperidine compounds OHMEDA PHARMA PROD (US) 1994-06-01 EP claimed