Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21477111 | 0.82 | MAPT (0.35) | MAPTKDM4CGAA | |
| SCHEMBL24717955 | 0.79 | MEN1 (0.37) | MAPTKDM4CGAA | |
| SCHEMBL20231587 | 0.75 | MAPT (0.37) | MAPTKDM4CGAA | |
| SCHEMBL17169693 | 0.71 | PKM (0.39) | MAPTKDM4CGAA | |
| SCHEMBL20128636 | 0.69 | MAPT (0.39) | MAPTKDM4C | |
| SCHEMBL22297065 | 0.68 | — | — | |
| SCHEMBL21664557 | 0.67 | MEN1 (0.41) | MAPTKDM4CGAA | |
| SCHEMBL29829520 | 0.62 | MAPT (0.37) | MAPTKDM4C | |
| SCHEMBL21664602 | 0.62 | MAPT (0.37) | MAPTKDM4CGAA | |
| SCHEMBL17169678 | 0.62 | MAPT (0.45) | MAPTKDM4CGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018102725-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas, Inc. (US) | 2018-06-07 | — | — | WO | disclosed |