Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.33 |
| ▸ | CDC42BPB | Q9Y5S2 | 8/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.33 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29829485 | 0.81 | MAPT (0.36) | MAPTKDM4CALDH1A1F2RL1LRRK2 | |
| SCHEMBL29829678 | 0.74 | NT5E (0.51) | MAPTKDM4CALDH1A1F2RL1LRRK2 | |
| SCHEMBL29829373 | 0.71 | ALDH1A1 (0.39) | MAPTALDH1A1 | |
| SCHEMBL25004243 | 0.70 | NT5E (0.38) | MAPTKDM4CF2RL1LRRK2NT5E | |
| SCHEMBL23994437 | 0.70 | NT5E (0.38) | MAPTKDM4CF2RL1LRRK2NT5E | |
| SCHEMBL29829627 | 0.70 | NT5E (0.48) | MAPTKDM4CROCK1CDC42BPBROCK2 | |
| SCHEMBL25004807 | 0.68 | NT5E (0.34) | MAPTKDM4CF2RL1LRRK2NT5E | |
| SCHEMBL17169693 | 0.65 | PKM (0.39) | MAPTKDM4CALDH1A1 | |
| SCHEMBL29829512 | 0.65 | NT5E (0.48) | MAPTKDM4CNT5E | |
| SCHEMBL23995415 | 0.64 | KDM4E (0.39) | MAPTALDH1A1NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022195499-A1 | SUBSTITUTED PYRIDAZINE COMPOUNDS AS CD73 INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2022-09-22 | — | — | WO | disclosed |