Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.38 |
| ▸ | F2R | P25116 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CPN1 | P15169 | 1/20 | 0.35 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14549450 | 0.92 | MAPT (0.39) | MEN1KMT2APOLBMAPTNPC1 | |
| SCHEMBL20892956 | 0.92 | MEN1 (0.47) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL13741632 | 0.85 | ALDH1A1 (0.41) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL24023958 | 0.84 | CHRNB2 (0.36) | SMN1; SMN2NPC1SIGMAR1 | |
| SCHEMBL16886105 | 0.83 | MEN1 (0.53) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL20082923 | 0.83 | MEN1 (0.53) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL12384628 | 0.83 | NPC1 (0.44) | MAPTALDH1A1NPC1CPN1CPB2 | |
| SCHEMBL21937928 | 0.81 | MEN1 (0.66) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL26731261 | 0.80 | MEN1 (0.45) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL26936170 | 0.80 | KMT2A (0.65) | MEN1KMT2APOLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018102419-A1 | COMPOUNDS CONTAINING A SULFONIC GROUP AS KAT INHIBITORS | Epizyme, Inc. (US) | 2018-06-07 | — | — | WO | disclosed |