Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | FURIN | P09958 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20235749 | 0.89 | CACNA1B (0.41) | SIRT6SIRT1CACNA1BCAPN1FOLH1 | |
| SCHEMBL16234102 | 0.87 | CACNA1B (0.42) | SIRT6SIRT1CACNA1BCAPN1FOLH1 | |
| SCHEMBL16234093 | 0.80 | CACNA1B (0.41) | SIRT6SIRT1CACNA1BCAPN1FURIN | |
| SCHEMBL20235517 | 0.80 | FURIN (0.41) | SIRT6SIRT1CAPN1FOLH1SIRT5 | |
| SCHEMBL20235751 | 0.79 | NMT2 (0.41) | SIRT6SIRT1CACNA1BFURINPRSS1 | |
| SCHEMBL16231518 | 0.79 | CAPN1 (0.39) | SIRT6SIRT1CACNA1BCAPN1FOLH1 | |
| SCHEMBL16234089 | 0.77 | FURIN (0.41) | SIRT6SIRT1CAPN1FOLH1SIRT5 | |
| SCHEMBL20235704 | 0.77 | CACNA1B (0.40) | CACNA1BCAPN1FOLH1FURINPRSS1 | |
| SCHEMBL20235575 | 0.76 | CAPN1 (0.38) | SIRT6SIRT1CAPN1FOLH1SIRT5 | |
| SCHEMBL20235783 | 0.76 | CACNA1B (0.38) | CACNA1BCAPN1FURINPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10626438-B2 | Fluorescent substrates for determining lysine modifying enzyme activity | THE BROAD INSTITUTE, INC. (US) | 2020-04-21 | — | — | US | disclosed |
| US-20180155760-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | BROAD INST INC (US) | 2018-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155760-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | KDM1A, MAN2B1, KDM3A | SIRT6 691/4885SIRT1 396/4885CACNA1B 3145/4885 |
| US-10626438-B2 | Fluorescent substrates for determining lysine modifying enzyme activity | KDM1A, MAN2B1, KDM3A | SIRT6 691/4885SIRT1 396/4885CACNA1B 3145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.