Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.37 |
| ▸ | NPY4R | P50391 | 4/20 | 0.37 |
| ▸ | NPY1R | P25929 | 3/20 | 0.37 |
| ▸ | NPY2R | P49146 | 3/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | FURIN | P09958 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16234102 | 0.91 | CACNA1B (0.42) | CACNA1BPSMB5CAPN1SIRT6SIRT1 | |
| SCHEMBL16234097 | 0.88 | CACNA1B (0.41) | CACNA1BCAPN1FURIN | |
| SCHEMBL16234039 | 0.85 | CACNA1B (0.41) | CACNA1BMEN1KMT2ACAPN1NPY4R | |
| SCHEMBL14932579 | 0.84 | CACNA1B (0.38) | CACNA1BCAPN1SIRT6SIRT1KISS1R | |
| SCHEMBL14932630 | 0.84 | NMT2 (0.44) | CACNA1BSIRT6SIRT1OPRK1FURIN | |
| SCHEMBL20235749 | 0.81 | CACNA1B (0.41) | CACNA1BPSMB5CAPN1SIRT6SIRT1 | |
| SCHEMBL14932589 | 0.81 | PSMB5 (0.40) | PSMB5MEN1KMT2ACAPN1NPY4R | |
| SCHEMBL20235576 | 0.80 | SIRT6 (0.39) | CACNA1BPSMB5CAPN1SIRT6SIRT1 | |
| SCHEMBL16234089 | 0.80 | FURIN (0.41) | CAPN1SIRT6SIRT1OPRK1FURIN | |
| SCHEMBL16231525 | 0.80 | PSMB5 (0.39) | PSMB5MEN1KMT2ACAPN1NPY4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10626438-B2 | Fluorescent substrates for determining lysine modifying enzyme activity | THE BROAD INSTITUTE, INC. (US) | 2020-04-21 | — | — | US | disclosed |
| US-20180155760-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | BROAD INST INC (US) | 2018-06-07 | — | — | US | disclosed |
| US-20140335550-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | THE BROAD INSTITUTE, INC. (US) | 2014-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155760-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | KDM1A, MAN2B1, KDM3A | CACNA1B 3145/4885PSMB5 1017/4885MEN1 536/4885 |
| US-10626438-B2 | Fluorescent substrates for determining lysine modifying enzyme activity | KDM1A, MAN2B1, KDM3A | CACNA1B 3145/4885PSMB5 1017/4885MEN1 536/4885 |
| US-20140335550-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | MAN2B1, KDM1A, KDM3A | CACNA1B 3318/4885PSMB5 890/4885MEN1 666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.