Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 3/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2025052 | 1.00 | PDE8B (0.33) | PDE8BBRD4NOS2 | |
| SCHEMBL2023900 | 1.00 | PDE8B (0.33) | PDE8BBRD4NOS2 | |
| SCHEMBL2025053 | 1.00 | PDE8B (0.33) | PDE8BBRD4NOS2 | |
| SCHEMBL2023906 | 1.00 | PDE8B (0.33) | PDE8BBRD4NOS2 | |
| SCHEMBL2023903 | 1.00 | PDE8B (0.33) | PDE8BBRD4NOS2 | |
| SCHEMBL1567543 | 0.75 | — | — | |
| SCHEMBL2023890 | 0.75 | — | — | |
| SCHEMBL2022535 | 0.75 | — | — | |
| SCHEMBL2023891 | 0.75 | — | — | |
| SCHEMBL2028005 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580823-B2 | Piperidine renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2013-11-12 | — | — | US | disclosed |
| EP-2074108-B3 | RENIN INHIBITORS | VITAE PHARMACEUTICALS INC (US) | 2013-06-26 | — | — | EP | disclosed |
| EP-2581366-A1 | Renin Inhibitors | Vitae Pharmaceuticals, Inc. (US) | 2013-04-17 | — | — | EP | disclosed |
| EP-2074108-B1 | RENIN INHIBITORS | VITAE PHARMACEUTICALS INC (US) | 2012-11-21 | — | — | EP | disclosed |
| US-20120225906-A1 | PIPERIDINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. | 2012-09-06 | — | — | US | disclosed |
| US-8198453-B2 | Piperidine renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2012-06-12 | — | — | US | disclosed |
| US-20110160300-A1 | Renin Inhibitors and Methods of Use Thereof | VITAE PHARMACEUTICALS, INC. | 2011-06-30 | — | — | US | disclosed |
| US-20100311989-A1 | PROCESS FOR THE PREPARATION OF RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. | 2010-12-09 | — | — | US | disclosed |
| US-20100160424-A1 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. | 2010-06-24 | — | — | US | disclosed |
| US-20090312369-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS , INC. | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225906-A1 | PIPERIDINE RENIN INHIBITORS | ACE, PEPD, DNPEP | PDE8B 2156/4885BRD4 1079/4885NOS2 2576/4885 |
| US-20100160424-A1 | RENIN INHIBITORS | ACE, REN, DNPEP | PDE8B 1224/4885BRD4 1213/4885NOS2 4071/4885 |
| US-20110160300-A1 | Renin Inhibitors and Methods of Use Thereof | REN, ACE, AGTR1 | PDE8B 513/4885BRD4 2107/4885NOS2 2541/4885 |
| US-20100311989-A1 | PROCESS FOR THE PREPARATION OF RENIN INHIBITORS | REN, ACE, AGTR1 | PDE8B 748/4885BRD4 1832/4885NOS2 1023/4885 |
| US-20090312369-A1 | Renin Inhibitors | ACE, REN, DNPEP | PDE8B 1687/4885BRD4 2248/4885NOS2 3295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.