Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.70 |
| ▸ | BRAF | P15056 | 8/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.67 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.67 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.60 |
| ▸ | GCGR | P47871 | 2/20 | 0.58 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.56 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28406403 | 0.88 | MAPK13 (0.70) | RAF1BRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL7643418 | 0.82 | BRAF (1.00) | RAF1BRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL29355176 | 0.82 | BRAF (1.00) | RAF1BRAFMAPK14MAPK13MAPK12 | |
| Bromide SCHEMBL7648283 | 0.81 | BRAF (0.95) | RAF1BRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL28486758 | 0.80 | MAPK14 (1.00) | RAF1BRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL6469877 | 0.80 | MAPK14 (1.00) | RAF1BRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL6470001 | 0.80 | MAPK14 (0.70) | RAF1BRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL12856388 | 0.80 | BRAF (0.90) | RAF1BRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL4471392 | 0.80 | MAPK14 (0.79) | RAF1BRAFMAPK14MAPK13MAPK12 | |
| SCHEMBL28397228 | 0.80 | MAPK13 (0.70) | RAF1BRAFMAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548030-A1 | PRESERVATION OF IMMUNE RESPONSE DURING CHEMOTHERAPY REGIMENS | G1 Therapeutics, Inc. (US) | 2019-10-09 | — | — | EP | disclosed |
| WO-2018106729-A1 | PRESERVATION OF IMMUNE RESPONSE DURING CHEMOTHERAPY REGIMENS | G1 THERAPEUTICS, INC. (US) | 2018-06-14 | — | — | WO | disclosed |