Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.49 |
| ▸ | JAK1 | P23458 | 4/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 3/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20246551 | 0.90 | JAK1 (0.46) | JAK2JAK1ROCK2 | |
| SCHEMBL20245921 | 0.89 | JAK1 (0.50) | JAK2JAK1ROCK2 | |
| SCHEMBL20246183 | 0.85 | JAK1 (0.50) | JAK2JAK1ROCK2SMN1; SMN2GLS | |
| SCHEMBL20246362 | 0.85 | SMN1; SMN2 (0.38) | JAK2JAK1SMN1; SMN2ACKR3 | |
| SCHEMBL20246357 | 0.83 | SMN1; SMN2 (0.37) | JAK2JAK1SMN1; SMN2ACKR3 | |
| SCHEMBL20246380 | 0.83 | JAK2 (0.49) | JAK2JAK1ACKR3 | |
| SCHEMBL20246136 | 0.81 | SMN1; SMN2 (0.40) | JAK2JAK1SMN1; SMN2ACKR3 | |
| SCHEMBL20246288 | 0.81 | JAK1 (0.45) | JAK2JAK1SMN1; SMN2ACKR3 | |
| SCHEMBL20246160 | 0.81 | JAK2 (0.42) | JAK2JAK1SMN1; SMN2ACKR3 | |
| SCHEMBL24732888 | 0.79 | ROCK2 (0.54) | JAK2JAK1ROCK2CCKBRBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2976340-B1 | CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-06-13 | — | — | EP | disclosed |