Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | TLK2 | Q86UE8 | 4/20 | 0.63 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.63 |
| ▸ | RET | P07949 | 5/20 | 0.61 |
| ▸ | CDK2 | P24941 | 4/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.61 |
| ▸ | CDK1 | P06493 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | GSK3A | P49840 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | CDK7 | P50613 | 2/20 | 0.60 |
| ▸ | CDK9 | P50750 | 2/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.60 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19928099 | 1.00 | ALDH1A1 (0.66) | ALDH1A1TLK2PDPK1RETCDK2 | |
| SCHEMBL10398623 | 0.84 | ALDH1A1 (0.62) | ALDH1A1TLK2PDPK1RETCDK2 | |
| SCHEMBL10398625 | 0.84 | ALDH1A1 (0.62) | ALDH1A1TLK2PDPK1RETCDK2 | |
| SCHEMBL14446692 | 0.82 | CES1 (0.67) | ALDH1A1TLK2PDPK1RETCDK2 | |
| SCHEMBL28369943 | 0.81 | RET (0.68) | ALDH1A1TLK2PDPK1RETCDK2 | |
| SCHEMBL29705973 | 0.81 | RET (0.68) | ALDH1A1TLK2PDPK1RETCDK2 | |
| 5-Methoxyisatin SCHEMBL29506298 | 0.80 | ALDH1A1 (1.00) | ALDH1A1TLK2PDPK1RETLRRK2 | |
| 5-Methoxyisatin SCHEMBL21602 | 0.80 | ALDH1A1 (1.00) | ALDH1A1TLK2PDPK1RETLRRK2 | |
| SCHEMBL17179569 | 0.79 | TLK2 (0.64) | ALDH1A1TLK2PDPK1RETCDK2 | |
| SCHEMBL29705833 | 0.79 | GSK3B (0.66) | ALDH1A1TLK2PDPK1RETCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2892525-B1 | METHODS OF TREATING MUSCULAR DYSTROPHY | UNIV NEVADA RENO (US) | 2018-06-13 | — | — | EP | disclosed |