Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 16/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 14/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | GAA | P10253 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | PKM | P14618 | 3/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 13/20 | 0.59 |
| ▸ | HPGD | P15428 | 8/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
| ▸ | CASP1 | P29466 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20250918 | 0.87 | ALDH1A1 (0.78) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL20248200 | 0.87 | KDM4E (0.78) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL9763051 | 0.78 | ALDH1A1 (0.76) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL20248140 | 0.78 | ALDH1A1 (0.63) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL20248153 | 0.78 | ALDH1A1 (0.63) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL19270610 | 0.74 | ALDH1A1 (0.79) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL14285635 | 0.74 | ALDH1A1 (1.00) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL17211755 | 0.74 | CNKSR1 (1.00) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL20248187 | 0.69 | ALDH1A1 (0.85) | ALDH1A1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL9763027 | 0.69 | MEN1 (0.81) | ALDH1A1KDM4EKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180161313-A1 | Inhibitors of Mcl-1 as Drugs to Overcome Resistance to BRAF Inhibitors and MEK Inhibitors | TEXAS TECH UNIVERSITY SYSTEM | 2018-06-14 | — | — | US | disclosed |
| US-20180161313-A1 | Inhibitors of Mcl-1 as Drugs to Overcome Resistance to BRAF Inhibitors and MEK Inhibitors | TEXAS TECH UNIVERSITY SYSTEM | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180161313-A1 | Inhibitors of Mcl-1 as Drugs to Overcome Resistance to BRAF Inhibitors and MEK Inhibitors | MCL1, BRAF, RAF1 | ALDH1A1 2512/4885KDM4E 1895/4885KMT2A 1550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.