Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNKSR1 | Q969H4 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.79 |
| ▸ | POLB | P06746 | 7/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.79 |
| ▸ | RECQL | P46063 | 2/20 | 0.79 |
| ▸ | GAA | P10253 | 2/20 | 0.79 |
| ▸ | CASP6 | P55212 | 1/20 | 0.79 |
| ▸ | HPGD | P15428 | 5/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | USP2 | O75604 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17211717 | 0.92 | CNKSR1 (0.85) | CNKSR1ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL19270610 | 0.85 | ALDH1A1 (0.79) | CNKSR1ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL14285635 | 0.85 | ALDH1A1 (1.00) | CNKSR1ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL14865018 | 0.82 | KDM4E (0.85) | CNKSR1ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL17211702 | 0.78 | ALDH1A1 (0.85) | CNKSR1ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL9763051 | 0.78 | ALDH1A1 (0.76) | CNKSR1ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL1903643 | 0.75 | MEN1 (1.00) | CNKSR1ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL20248201 | 0.74 | ALDH1A1 (0.62) | CNKSR1ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL20248187 | 0.74 | ALDH1A1 (0.85) | CNKSR1ALDH1A1KDM4EHSD17B10POLB | |
| SCHEMBL20250918 | 0.74 | ALDH1A1 (0.78) | CNKSR1ALDH1A1KDM4EHSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2931280-B1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS INC (US) | 2018-02-14 | — | — | EP | disclosed |
| US-9340532-B2 | Methods and compositions for inhibiting CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-9340532-B2 | Methods and compositions for inhibiting CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150307482-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150307482-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | PHUSIS THERAPEUTICS, INC. (US) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307482-A1 | METHODS AND COMPOSITIONS FOR INHIBITING CNKSR1 | CNKSR1, CAMKK1, CAMKK2 | CNKSR1 1/4885ALDH1A1 4764/4885KDM4E 770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.