Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20249318 | 0.83 | PTPN11 (0.37) | PTPN11MAPK3MAPK1 | |
| SCHEMBL20249370 | 0.82 | SCD (0.36) | PTPN11 | |
| SCHEMBL18290954 | 0.80 | PTPN11 (0.45) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL18291284 | 0.80 | PTPN11 (0.45) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL20038134 | 0.79 | OGA (0.41) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL20249268 | 0.78 | HRH4 (0.51) | — | |
| SCHEMBL20249305 | 0.77 | TRPV1 (0.39) | — | |
| SCHEMBL20249130 | 0.77 | ALDH1A1 (0.51) | — | |
| SCHEMBL20249099 | 0.77 | BPTF (0.57) | MAPK1 | |
| SCHEMBL20249147 | 0.74 | LMNA (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TEIJIN PHARMA LIMITED (JP) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | CDK4, CDK6, CDK16 | PTPN11 200/4885KCNH2 3160/4885MAPK3 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.