Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20249147 | 0.81 | LMNA (0.40) | HSD11B1MEN1KMT2ASMN1; SMN2PTGER4 | |
| SCHEMBL20249263 | 0.79 | CDK4 (0.39) | MAP4K4HRH3 | |
| SCHEMBL20249141 | 0.79 | LMNA (0.38) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20249235 | 0.79 | HRH4 (0.48) | MEN1KMT2ASMN1; SMN2HRH3 | |
| SCHEMBL21588395 | 0.78 | KMT2A (0.63) | MAP4K4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18291736 | 0.78 | MAP4K4 (0.52) | MAP4K4MEN1KMT2ASMN1; SMN2HRH3 | |
| SCHEMBL20038269 | 0.78 | MAP4K4 (0.46) | MAP4K4MEN1KMT2ASMN1; SMN2HRH3 | |
| SCHEMBL24621818 | 0.77 | DGAT1 (0.35) | MEN1KMT2ASMN1; SMN2HRH3 | |
| SCHEMBL20249466 | 0.77 | LMNA (0.63) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20249359 | 0.76 | TRPV1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TEIJIN PHARMA LIMITED (JP) | 2018-06-14 | — | — | US | disclosed |
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TEIJIN PHARMA LIMITED (JP) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | CDK4, CDK6, CDK16 | MAP4K4 191/4885HSD11B1 1477/4885MEN1 2609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.