SCHEMBL2025155

SCHEMBL2025155

Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O

nearest known ligand 0.87

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RY1 P47900 11/20 0.87
P2RY11 Q96G91 5/20 0.83
NT5E P21589 1/20 0.77
ENPP1 P22413 2/20 0.76
P2RY12 Q9H244 1/20 0.76
P2RX1 P51575 2/20 0.75
P2RX3 P56373 2/20 0.75
P2RX4 Q99571 2/20 0.75
P2RY6 Q15077 1/20 0.75
RNASEL Q05823 1/20 0.71
GPR17 Q13304 1/20 0.70
ADORA3 P0DMS8 1/20 0.69
P2RY2 P41231 2/20 0.69
SRC P12931 1/20 0.69
P2RX2 Q9UBL9 1/20 0.69
CA1 P00915 1/20 0.69
CA2 P00918 1/20 0.69
CA4 P22748 1/20 0.69
CA9 Q16790 1/20 0.69
ALDH1A1 P00352 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2025163 1.00 P2RY1 (0.87) P2RY1P2RY11NT5EENPP1P2RY12
SCHEMBL15082695 0.99 P2RY1 (0.85) P2RY1P2RY11NT5EENPP1P2RY12
SCHEMBL2027164 0.99 P2RY1 (0.85) P2RY1P2RY11NT5EENPP1P2RY12
SCHEMBL29880723 0.99 P2RY1 (0.85) P2RY1P2RY11NT5EENPP1P2RY12
SCHEMBL2027165 0.99 P2RY1 (0.85) P2RY1P2RY11NT5EENPP1P2RY12
SCHEMBL18089329 0.94 P2RY1 (0.77) P2RY1P2RY11NT5EENPP1P2RY12
SCHEMBL18089799 0.93 P2RY1 (0.77) P2RY1P2RY11NT5EENPP1P2RY12
SCHEMBL8423419 0.92 P2RY1 (0.83) P2RY1P2RY11NT5EP2RX3RNASEL
SCHEMBL10120960 0.92 P2RY1 (0.83) P2RY1P2RY11NT5EP2RX3RNASEL
SCHEMBL8423402 0.92 P2RY1 (0.83) P2RY1P2RY11NT5EP2RX3RNASEL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7960131-B2 Functional genomic pore assay for mixed cell populations WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2011-06-14 US claimed
US-7560243-B2 White blood cell functional assay WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2009-07-14 US claimed
US-20090053204-A1 Functional Genomic Pore Assay For Mixed Cell Populations WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2009-02-26 US claimed
US-20040253650-A1 White blood cell functional assay WISCONSIN ALUMNI RESEARCH FOUNDATION 2004-12-16 US claimed
US-7960131-B2 Functional genomic pore assay for mixed cell populations WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2011-06-14 US disclosed
US-7560243-B2 White blood cell functional assay WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2009-07-14 US disclosed
US-20090053204-A1 Functional Genomic Pore Assay For Mixed Cell Populations WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2009-02-26 US disclosed
US-20040253650-A1 White blood cell functional assay WISCONSIN ALUMNI RESEARCH FOUNDATION 2004-12-16 US disclosed