Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY1 | P47900 | 7/20 | 0.83 |
| ▸ | P2RY11 | Q96G91 | 5/20 | 0.83 |
| ▸ | NT5E | P21589 | 3/20 | 0.82 |
| ▸ | CA5A | P35218 | 1/20 | 0.79 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.74 |
| ▸ | CA1 | P00915 | 1/20 | 0.74 |
| ▸ | CA2 | P00918 | 1/20 | 0.74 |
| ▸ | CA4 | P22748 | 1/20 | 0.74 |
| ▸ | CA9 | Q16790 | 1/20 | 0.74 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.73 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.73 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.73 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.73 |
| ▸ | LDHA | P00338 | 1/20 | 0.73 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.73 |
| ▸ | FBP1 | P09467 | 1/20 | 0.73 |
| ▸ | SRC | P12931 | 1/20 | 0.73 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.73 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.73 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8423419 | 1.00 | P2RY1 (0.83) | P2RY1P2RY11NT5ECA5AADORA3 | |
| SCHEMBL8423402 | 1.00 | P2RY1 (0.83) | P2RY1P2RY11NT5ECA5AADORA3 | |
| SCHEMBL2025155 | 0.92 | P2RY1 (0.87) | P2RY1P2RY11NT5EADORA3CA1 | |
| SCHEMBL2025163 | 0.92 | P2RY1 (0.87) | P2RY1P2RY11NT5EADORA3CA1 | |
| SCHEMBL2027165 | 0.92 | P2RY1 (0.85) | P2RY1P2RY11NT5EADORA3SRC | |
| SCHEMBL2027164 | 0.92 | P2RY1 (0.85) | P2RY1P2RY11NT5EADORA3SRC | |
| SCHEMBL15082695 | 0.92 | P2RY1 (0.85) | P2RY1P2RY11NT5EADORA3SRC | |
| SCHEMBL29880723 | 0.92 | P2RY1 (0.85) | P2RY1P2RY11NT5EADORA3SRC | |
| SCHEMBL14074374 | 0.91 | NT5E (0.83) | P2RY1P2RY11NT5ECA5AADORA3 | |
| SCHEMBL9136027 | 0.91 | NT5E (0.83) | P2RY1P2RY11NT5ECA5AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9526739-B2 | Compositions and methods to treat cardiac diseases | UNIVERSITY OF CONNECTICUT (US) | 2016-12-27 | — | — | US | disclosed |
| US-9526739-B2 | Compositions and methods to treat cardiac diseases | UNIVERSITY OF CONNECTICUT (US) | 2016-12-27 | — | — | US | disclosed |
| US-20160166591-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | GOOGLE LLC | 2016-06-16 | — | — | US | disclosed |
| US-20160166591-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | GOOGLE LLC | 2016-06-16 | — | — | US | disclosed |
| US-9303053-B2 | Compositions and methods to treat cardiac diseases | UNIVERSITY OF CONNECTICUT (US) | 2016-04-05 | — | — | US | disclosed |
| US-9303053-B2 | Compositions and methods to treat cardiac diseases | UNIVERSITY OF CONNECTICUT (US) | 2016-04-05 | — | — | US | disclosed |
| US-20150038463-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | UNIV CONNECTICUT (US) | 2015-02-05 | — | — | US | disclosed |
| US-20150038463-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | UNIV CONNECTICUT (US) | 2015-02-05 | — | — | US | disclosed |
| US-8822434-B2 | Compositions and methods to treat cardiac diseases | THE UNIVERSITY OF CONNECTICUT (US) | 2014-09-02 | — | — | US | disclosed |
| US-8822434-B2 | Compositions and methods to treat cardiac diseases | THE UNIVERSITY OF CONNECTICUT (US) | 2014-09-02 | — | — | US | disclosed |
| WO-2011103552-A9 | AMP DERIVATIVES FOR TREATING CARDIAC DISEASES | UNIVERSITY OF CONNECTICUT (US) | 2012-04-26 | — | — | WO | disclosed |
| US-20110212924-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | UNIVERSITY OF CONNECTICUT | 2011-09-01 | — | — | US | disclosed |
| US-20110212924-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | UNIVERSITY OF CONNECTICUT | 2011-09-01 | — | — | US | disclosed |
| WO-2011103552-A2 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | UNIVERSITY OF CONNECTICUT (US) | 2011-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212924-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | P2RY12, P2RX6, P2RY14 | P2RY1 4/4885P2RY11 13/4885NT5E 486/4885 |
| US-20150038463-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | P2RY12, P2RX6, P2RY14 | P2RY1 4/4885P2RY11 13/4885NT5E 486/4885 |
| US-20160166591-A1 | COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES | P2RY12, P2RX6, P2RY14 | P2RY1 4/4885P2RY11 13/4885NT5E 486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.