Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20241151 | 0.81 | LRRK2 (0.42) | ANO1NPC1RAB9AIRAK4 | |
| SCHEMBL30166593 | 0.81 | LRRK2 (0.42) | ANO1NPC1RAB9AIRAK4 | |
| SCHEMBL20254998 | 0.80 | ANO1 (0.35) | ANO1KDRPDE4APDE4BPDE4C | |
| SCHEMBL15999441 | 0.80 | OPRK1 (0.46) | SORT1MAPTSMN1; SMN2OPRK1CNR2 | |
| SCHEMBL13555770 | 0.76 | KDM4E (0.50) | ANO1NPC1MAPK1RAB9ATP53 | |
| SCHEMBL13555773 | 0.75 | BACE1 (0.42) | HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL20995140 | 0.75 | BMPR1B (0.52) | OPRK1CNR2 | |
| SCHEMBL20995143 | 0.75 | BMPR1B (0.52) | OPRK1CNR2 | |
| SCHEMBL30854837 | 0.75 | CNR2 (0.51) | NPC1RAB9ASMN1; SMN2OPRK1CNR2 | |
| SCHEMBL20240901 | 0.75 | CNR2 (0.51) | NPC1RAB9ASMN1; SMN2OPRK1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018104214-A1 | METHOD FOR PRODUCING 5-(1-PHENYL-1H-PYRAZOLE-4-YL)-NICOTINAMIDE DERIVATIVES AND SIMILAR COMPOUNDS WITHOUT ISOLATING OR PURIFYING THE PHENYLHYDRAZINE INTERMEDIATE | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2018-06-14 | — | — | WO | disclosed |