Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | TPO | P07202 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16355195 | 0.79 | KDM4E (0.48) | LMNAKMT2AGAACYP2D6CYP2C9 | |
| SCHEMBL23613102 | 0.77 | L3MBTL1 (0.57) | LMNAKMT2AGAANPSR1L3MBTL1 | |
| SCHEMBL10203575 | 0.76 | MEN1 (0.36) | LMNAKMT2ATAAR1PDE2AALDH1A1 | |
| SCHEMBL765891 | 0.76 | TAAR1 (0.39) | HTTTAAR1MAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL14290420 | 0.76 | SLC6A4 (0.45) | TAAR1PDE2AALDH1A1HTR2CSLC6A4 | |
| SCHEMBL13104119 | 0.75 | SCN8A (0.41) | KMT2AGAASCN8AMPOMEN1 | |
| SCHEMBL10565368 | 0.74 | ADH1B (0.37) | TAAR1PDE2AALDH1A1PTGS2 | |
| SCHEMBL13965848 | 0.73 | SMN1; SMN2 (0.36) | HTTPDE2ASCN8AMPOSMN1; SMN2 | |
| SCHEMBL13104123 | 0.73 | HTT (0.53) | KMT2AL3MBTL1HTTSCN8AALDH1A1 | |
| SCHEMBL12561550 | 0.73 | TAAR1 (0.41) | HTTTAAR1HTR2CSLC6A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018104766-A1 | 3-(2,3-DIHYDRO-1H-INDEN-5-YL)PROPANOIC ACID DERIVATIVES AND THEIR USE AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-06-14 | — | — | WO | disclosed |