Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22305046 | 1.00 | LMNA (0.40) | LMNASIGMAR1CHRNA7MEN1CYP3A4 | |
| SCHEMBL20384069 | 0.79 | TSHR (0.35) | — | |
| SCHEMBL19788223 | 0.76 | LMNA (0.33) | LMNA | |
| SCHEMBL20384101 | 0.73 | SIGMAR1 (0.35) | SIGMAR1MEN1CYP3A4ALOX15KMT2A | |
| SCHEMBL20261092 | 0.69 | LMNA (0.41) | LMNACHRNA7MEN1CYP3A4ALOX15 | |
| SCHEMBL23508979 | 0.69 | SIGMAR1 (0.35) | SIGMAR1MEN1CYP3A4ALOX15KMT2A | |
| SCHEMBL11444225 | 0.68 | LMNA (0.40) | LMNACHRNA7MEN1CYP3A4ALOX15 | |
| SCHEMBL12891347 | 0.68 | LMNA (0.40) | LMNACHRNA7MEN1CYP3A4ALOX15 | |
| SCHEMBL27397885 | 0.68 | HRH3 (0.30) | HRH3 | |
| SCHEMBL14627262 | 0.67 | SIGMAR1 (0.46) | SIGMAR1MEN1CYP3A4ALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018107112-A1 | QUINOLONE-BASED COMPOUNDS WITH ANTICANCER ACTIVITY | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2018-06-14 | — | — | WO | disclosed |