Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 15/20 | 0.43 |
| ▸ | JAK2 | O60674 | 9/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20260507 | 0.93 | TBK1 (0.38) | TBK1JAK2PTK2MAPK8MAPK10 | |
| SCHEMBL20242673 | 0.89 | TBK1 (0.42) | TBK1JAK2PTK2FGFR3EGFR | |
| SCHEMBL20260500 | 0.89 | TBK1 (0.34) | TBK1JAK2PTK2MAPK8MAPK10 | |
| SCHEMBL20260873 | 0.86 | MAPT (0.42) | JAK2FGFR3MAPK8MAPK10 | |
| SCHEMBL20260540 | 0.86 | TBK1 (0.35) | TBK1JAK2PTK2FGFR3EGFR | |
| SCHEMBL20260536 | 0.84 | TBK1 (0.40) | TBK1JAK2 | |
| SCHEMBL20260502 | 0.84 | TBK1 (0.43) | TBK1JAK2PTK2MAPK8MAPK10 | |
| SCHEMBL18278549 | 0.83 | MAPK8 (0.39) | TBK1JAK2MAPK8MAPK10 | |
| SCHEMBL18278277 | 0.83 | MAPK8 (0.39) | TBK1JAK2MAPK8MAPK10 | |
| SCHEMBL18278344 | 0.83 | MAPK8 (0.37) | TBK1JAK2MAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018106646-A1 | AMINOTRIAZOLES FOR THE TREATMENT OF DEMYELINATING DISEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-06-14 | — | — | WO | disclosed |