Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20260795 | 0.93 | MAPK10 (0.41) | MAPTMAPK10MAPK8MAPK9TDP1 | |
| SCHEMBL20260874 | 0.89 | MAPT (0.41) | MAPTMAPK10MAPK8MAPK9TDP1 | |
| SCHEMBL20242665 | 0.89 | MAPK10 (0.37) | MAPTMAPK10MAPK8MAPK9TDP1 | |
| SCHEMBL20260525 | 0.89 | MAPK10 (0.42) | MAPTMAPK10MAPK8MAPK9TP53 | |
| SCHEMBL20260877 | 0.86 | TBK1 (0.43) | MAPK10MAPK8FGFR3JAK2 | |
| SCHEMBL20260535 | 0.85 | MAPK10 (0.38) | MAPTMAPK10MAPK8MAPK9TP53 | |
| SCHEMBL18278116 | 0.84 | MAPK10 (0.42) | MAPTMAPK10MAPK8MAPK9TP53 | |
| SCHEMBL20260395 | 0.83 | P2RX7 (0.39) | MAPTMAPK10MAPK8MAPK9JAK2 | |
| SCHEMBL18277906 | 0.83 | MAPK10 (0.40) | MAPTMAPK10MAPK8MAPK9TP53 | |
| SCHEMBL20260924 | 0.83 | MAPK8 (0.35) | MAPK10MAPK8MAPK9STAT6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018106646-A1 | AMINOTRIAZOLES FOR THE TREATMENT OF DEMYELINATING DISEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-06-14 | — | — | WO | disclosed |