Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20267266 | 1.00 | PPM1B (0.49) | PPM1BPTPN1PPP1CCMAPTALDH1A1 | |
| SCHEMBL15071090 | 1.00 | PPM1B (0.49) | PPM1BPTPN1PPP1CCMAPTALDH1A1 | |
| SCHEMBL5968081 | 0.94 | PPM1B (0.45) | PPM1BPTPN1PPP1CCMAPTALDH1A1 | |
| SCHEMBL6141464 | 0.92 | — | — | |
| SCHEMBL526510 | 0.92 | PPM1B (0.55) | PPM1BPTPN1PPP1CCMAPTALDH1A1 | |
| SCHEMBL12947777 | 0.89 | ALDH1A1 (0.45) | PPM1BPTPN1PPP1CCALDH1A1HCAR2 | |
| SCHEMBL11776740 | 0.87 | NAAA (0.48) | ALDH1A1SMN1; SMN2HCAR2 | |
| SCHEMBL1297212 | 0.86 | MAPT (0.51) | PPM1BPTPN1PPP1CCMAPTALDH1A1 | |
| SCHEMBL15071095 | 0.85 | NAAA (0.52) | SMN1; SMN2HCAR2 | |
| SCHEMBL1296724 | 0.84 | PPM1B (0.49) | PPM1BPTPN1PPP1CCALDH1A1HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551633-A1 | SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2019-10-16 | — | — | EP | disclosed |
| WO-2018108230-A1 | SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2018-06-21 | — | — | WO | disclosed |